Estimators of translocations and inversions in comparative maps

Authors:
David Sankoff;Matthew Mazowita
Affiliations:
Department of Mathematics and Statistics, University of Ottawa, Ottawa, ON, Canada;Department of Mathematics and Statistics, University of Ottawa, Ottawa, ON, Canada
Venue:
RCG'04 Proceedings of the 2004 RECOMB international conference on Comparative Genomics
Year:
2004

Citing 5
Cited 1

Conserved synteny as a measure of genomic distance

Discrete Applied Mathematics - Special volume on computational molecular biology
Efficient algorithms for multichromosomal genome rearrangements

Journal of Computer and System Sciences - Computational biology 2002
On the Nadeau-Taylor Theory of Conserved Chromosome Segments

CPM '97 Proceedings of the 8th Annual Symposium on Combinatorial Pattern Matching
Transforming men into mice (polynomial algorithm for genomic distance problem)

FOCS '95 Proceedings of the 36th Annual Symposium on Foundations of Computer Science
Chromosomal breakpoint re-use in the inference of genome sequence rearrangement

RECOMB '04 Proceedings of the eighth annual international conference on Resaerch in computational molecular biology

Stability of rearrangement measures in the comparison of genome sequences

RECOMB'05 Proceedings of the 9th Annual international conference on Research in Computational Molecular Biology

Quantified Score

Hi-index	0.00

Visualization

Abstract

In a comparative map, the number of translocations in the evolutionary history of a chromosome can be estimated solely on the basis of the conserved syntenies it contains. This estimate, subtracted from the number of conserved segments, then allows the estimation of the number of inversions that have affected the chromosome. Summing these estimates over all chromosomes provides a startlingly accurate estimator (as assessed by simulation) of the total number of rearrangements of each type occurring in the evolutionary divergence of two genomes.