Normalized similarity of RNA sequences

  • Authors:
  • Rolf Backofen;Danny Hermelin;Gad M. Landau;Oren Weimann

  • Affiliations:
  • Institute of Computer Science, Friedrich-Schiller Universität Jena, Jena Center for Bioinformatics, Germany;Department of Computer Science, University of Haifa, Israel;Department of Computer Science, University of Haifa, Haifa, Israel;Department of Computer Science, University of Haifa, Israel

  • Venue:
  • SPIRE'05 Proceedings of the 12th international conference on String Processing and Information Retrieval
  • Year:
  • 2005

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Abstract

We introduce a normalized version of the LCS metric as a new local similarity measure for comparing two RNAs. An $\mathcal{O}(n^{2}m{\rm lg}m)$ time algorithm is presented for computing the maximum normalized score of two RNA sequences, where n and m are the lengths of the sequences and n ≤ m. This algorithm has the same time complexity as the currently best known global LCS algorithm.