Unsupervised gene selection and clustering using simulated annealing

  • Authors:
  • Maurizio Filippone;Francesco Masulli;Stefano Rovetta

  • Affiliations:
  • Dipartimento di Informatica e Scienze dell'Informazione, Università di Genova, Genova, Italy;Dipartimento di Informatica, Università di Pisa, Pisa, Italy;Dipartimento di Informatica e Scienze dell'Informazione, Università di Genova, Genova, Italy

  • Venue:
  • WILF'05 Proceedings of the 6th international conference on Fuzzy Logic and Applications
  • Year:
  • 2005

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Abstract

When applied to genomic data, many popular unsupervised explorative data analysis tools based on clustering algorithms often fail due to their small cardinality and high dimensionality. In this paper we propose a wrapper method for gene selection based on simulated annealing and unsupervised clustering. The proposed approach, even if computationally intensive, permits to select the most relevant features (genes), and to rank their relevance, allowing to improve the results of clustering algorithms.