Learning bayesian classifiers from gene-expression microarray data

  • Authors:
  • Andrea Bosin;Nicoletta Dessì;Diego Liberati;Barbara Pes

  • Affiliations:
  • Dipartimento di Matematica e Informatica, Università degli Studi di Cagliari, Cagliari;Dipartimento di Matematica e Informatica, Università degli Studi di Cagliari, Cagliari;IEIIT CNR c/o Politecnico di Milano, Milano;Dipartimento di Matematica e Informatica, Università degli Studi di Cagliari, Cagliari

  • Venue:
  • WILF'05 Proceedings of the 6th international conference on Fuzzy Logic and Applications
  • Year:
  • 2005

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Abstract

Computing methods that allow the efficient and accurate processing of experimentally gathered data play a crucial role in biological research. The aim of this paper is to present a supervised learning strategy which combines concepts stemming from coding theory and Bayesian networks for classifying and predicting pathological conditions based on gene expression data collected from micro-arrays. Specifically, we propose the adoption of the Minimum Description Length (MDL) principle as a useful heuristic for ranking and selecting relevant features. Our approach has been successfully applied to the Acute Leukemia dataset and compared with different methods proposed by other researchers.