Journal of Biomedical Informatics
CRISTAL: A practical study in designing systems to cope with change
Information Systems
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The application of grid computing to biomedical research domains in the early years of the century has opened up promising prospects for the extension of this philosophy to translational medicine and hence to personalized healthcare. As the business side of the healthcare ‘enterprise' also moves to take advantage of the related technology of cloud computing, the management of personal healthcare data on one hand, and of medical knowledge on the other, come to the fore as the principal challenges for successful adoption. We conclude by exploring the potential role of agents to address this and related challenges.