Introduction to mathematical systems theory: a behavioral approach
Introduction to mathematical systems theory: a behavioral approach
Artificial chemistries—a review
Artificial Life
Discrete solutions to differential equations by metabolic P systems
Theoretical Computer Science
Process control: modeling, design, and simulation
Process control: modeling, design, and simulation
Towards evolutionary network reconstruction tools for systems biology
EvoBIO'07 Proceedings of the 5th European conference on Evolutionary computation, machine learning and data mining in bioinformatics
A protein substructure based p system for description and analysis of cell signalling networks
WMC'06 Proceedings of the 7th international conference on Membrane Computing
WMC'09 Proceedings of the 10th international conference on Membrane Computing
CMC'12 Proceedings of the 13th international conference on Membrane Computing
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Living organisms comprise astonishing capabilities of information processing for efficient adaptation to environmental changes. Resulting chemical control loops and regulator circuits are expected to exhibit a high functional similarity to technical counterparts subsumed by analog computers. A fascinating example is given by circadian clocks providing an endogenous biological rhythm adapted to the daily variation of sunlight and darkness. Its underlying biochemical principle of operation suggests a general functional scheme corresponding to frequency control using phase-locked loops (PLL). From a systems biology point of view, clock systems can be decomposed into specific modules like low-pass filters, arithmetic signal comparators, and controllable core oscillators. Each of them processes analog chemical signals on the fly. We introduce P modules in order to capture structure, behaviour, and interface of pure chemical analog computer models in terms of building blocks along with two simulation case studies. The first one is focused on chemical analog computer components including a controllable Goodwin-type core oscillator while the second one evolves an entire PLL-based frequency control by means of a pure chemical circadian clock model.