Spontaneous organization of the cortical structure through endogenous neural firing and gap junction transmission

  • Authors:

  • Myoung Won Cho;M. Y. Choi

  • Affiliations:

  • Department of Global Medical Science, Sungshin Women's University, Seoul 142-732, Republic of Korea;Department of Physics and Center for Theoretical Physics, Seoul National University, Seoul 151-747, Republic of Korea

  • Venue:
  • Neural Networks
  • Year:
  • 2012

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Abstract

We explore the effects of gap junctions, direct neural transmission between adjacent cells, on activity-dependent network formation. It is found that endogenous neural activities and weak firing correlations via gap junctions can regulate elaborately both the topographic structure in vertical connections and the radial structure in horizontal connections. Provided that pre-establishment of the lateral connection structure is required for the postnatal cortical map organization and genetic factors cannot perform such detailed regulation of synaptic connections, neural interactions via gap junctions could play an indispensable role in the brain development.