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This paper studies the performance of multiple-input-multiple-output (MIMO) systems with optimum combining in the presence of both co-channel interference (CCI) and noise. We assume that both desired and CCI users are subject to Rayleigh fading and allow the number of CCI users to be arbitrary and their short-term average powers to be non-identical. Given these assumptions, we derive exact results on the cumulative distribution function (CDF) of the output signal-to-interference-plus-noise ratio (SINR), or equivalently, the outage probability of this MIMO optimum combining scheme. Finally, we present and discuss some numerical examples to validate our analytical expressions and to show the effect of CCI on the performance of MIMO optimum combining systems