Machine Learning
Introduction to Data Mining, (First Edition)
Introduction to Data Mining, (First Edition)
Data Mining: Practical Machine Learning Tools and Techniques, Second Edition (Morgan Kaufmann Series in Data Management Systems)
Fuzzy lattice reasoning (FLR) classifier and its application for ambient ozone estimation
International Journal of Approximate Reasoning
Monitoring motor fluctuations in patients with Parkinson's disease using wearable sensors
IEEE Transactions on Information Technology in Biomedicine - Special section on body sensor networks
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Objective: In this study, a methodology is presented for an automated levodopa-induced dyskinesia (LID) assessment in patients suffering from Parkinson's disease (PD) under real-life conditions. Methods and Material: The methodology is based on the analysis of signals recorded from several accelerometers and gyroscopes, which are placed on the subjects' body while they were performing a series of standardised motor tasks as well as voluntary movements. Sixteen subjects were enrolled in the study. The recordings were analysed in order to extract several features and, based on these features, a classification technique was used for LID assessment, i.e. detection of LID symptoms and classification of their severity. Results: The results were compared with the clinical annotation of the signals, provided by two expert neurologists. The analysis was performed related to the number and topology of sensors used; several different experimental settings were evaluated while a 10-fold stratified cross validation technique was employed in all cases. Moreover, several different classification techniques were examined. The ability of the methodology to be generalised was also evaluated using leave-one-patient-out cross validation. The sensitivity and positive predictive values (average for all LID severities) were 80.35% and 76.84%, respectively. Conclusions: The proposed methodology can be applied in real-life conditions since it can perform LID assessment in recordings which include various PD symptoms (such as tremor, dyskinesia and freezing of gait) of several motor tasks and random voluntary movements.