A Bayesian expert system for the analysis of an adverse drug reaction

Authors:
R. G. Cowell;A. P. Dawid;T. Hutchinson;D. J. Spiegelhalter
Affiliations:
Department of Statistical Science, University College London, Gower Street, London WC1E 6BT, UK;Department of Statistical Science, University College London, Gower Street, London WC1E 6BT, UK;Royal Victoria Hospital, Montreal, Canada;MRC Biostatistics Unit, Cambridge, UK
Venue:
Artificial Intelligence in Medicine
Year:
1991

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Abstract

We describe a prototype probabilistic expert system which has been developed for analysing an adverse drug reaction problem, specifically, drug-induced pseudomembranous colitis. The system incorporates two simple Bayesian networks to model the main influences suspected to play a leading role in the adverse drug reaction. It uses the Lauritzen-Spiegelhalter algorithm for manipulating probability distributions in Bayesian networks.