Using quantitative and qualitative constraints in models of cardiac electrophysiology

  • Authors:
  • Jim Hunter;Ian Kirby;Nick Gotts

  • Affiliations:
  • Department of Computing Science, University of Aberdeen, King's College, Old Aberdeen AB9 2UB, UK;Department of Computing Science, University of Aberdeen, King's College, Old Aberdeen AB9 2UB, UK;Department of Zoology, University of Oxford, South Parks Road, Oxford, UK

  • Venue:
  • Artificial Intelligence in Medicine
  • Year:
  • 1991

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Abstract

A qualitative model of the electrical conducting system of the heart is developed which attempts to represent basic physiological and pathophysiological processes. The state descriptions and state transition rules are used to generate a tree of possible behaviours from a given start state. We demonstrate that without any further knowledge, explosive combinatorial branching occurs, but that information on state durations (expressed either quantitatively or qualitatively) can be employed to reduce very significantly the number of behaviours. An initial indication is given as to how the approach could be used to explain observed electrocardiograms (ECGs) in terms of the underlying physiological processes.