Introduction to the theory of neural computation
Introduction to the theory of neural computation
Parallel distributed processing: explorations in the microstructure of cognition, vol. 1: foundations
Self-organizing maps
Computer-aided diagnosis of breast lesions in medical images
Computing in Science and Engineering
Neural Networks for Pattern Recognition
Neural Networks for Pattern Recognition
Combining Artificial Neural Nets: Ensemble and Modular Multi-Net Systems
Combining Artificial Neural Nets: Ensemble and Modular Multi-Net Systems
Model selection for a medical diagnostic decision support system: a breast cancer detection case
Artificial Intelligence in Medicine
Learning adaptive kernels for model diagnosis
Design and application of hybrid intelligent systems
Inter-patient distance metrics using SNOMED CT defining relationships
Journal of Biomedical Informatics
Computers in Biology and Medicine
Artificial Intelligence in Medicine
Exploratory multilevel hot spot analysis: Australian taxation office case study
AusDM '07 Proceedings of the sixth Australasian conference on Data mining and analytics - Volume 70
Computers & Mathematics with Applications
Artificial Intelligence in Medicine
Indexes for three-class classification performance assessment: an empirical comparison
IEEE Transactions on Information Technology in Biomedicine
Impact of missing data in evaluating artificial neural networks trained on complete data
Computers in Biology and Medicine
Using hierarchical soft computing method to discriminate microcyte anemia
Expert Systems with Applications: An International Journal
IEEE Transactions on Systems, Man, and Cybernetics, Part B: Cybernetics
ICICS'07 Proceedings of the 9th international conference on Information and communications security
Artificial Intelligence in Medicine
Neural network based algorithms for diagnosis and classification of breast cancer tumor
CIS'05 Proceedings of the 2005 international conference on Computational Intelligence and Security - Volume Part I
Artificial Intelligence in Medicine
Artificial neural networks applied to cancer detection in a breast screening programme
Mathematical and Computer Modelling: An International Journal
Breast cancer detection using cartesian genetic programming evolved artificial neural networks
Proceedings of the 14th annual conference on Genetic and evolutionary computation
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The purpose of this study was to identify and characterize clusters in a heterogeneous breast cancer computer-aided diagnosis database. Identification of subgroups within the database could help elucidate clinical trends and facilitate future model building. A self-organizing map (SOM) was used to identify clusters in a large (2258 cases), heterogeneous computer-aided diagnosis database based on mammographic findings (BI-RADS(TM)) and patient age. The resulting clusters were then characterized by their prototypes determined using a constraint satisfaction neural network (CSNN). The clusters showed logical separation of clinical subtypes such as architectural distortions, masses, and calcifications. Moreover, the broad categories of masses and calcifications were stratified into several clusters (seven for masses and three for calcifications). The percent of the cases that were malignant was notably different among the clusters (ranging from 6 to 83%). A feed-forward back-propagation artificial neural network (BP-ANN) was used to identify likely benign lesions that may be candidates for follow up rather than biopsy. The performance of the BP-ANN varied considerably across the clusters identified by the SOM. In particular, a cluster (#6) of mass cases (6% malignant) was identified that accounted for 79% of the recommendations for follow up that would have been made by the BP-ANN. A classification rule based on the profile of cluster #6 performed comparably to the BP-ANN, providing approximately 25% specificity at 98% sensitivity. This performance was demonstrated to generalize to a large (2177) set of cases held-out for model validation.