Machine Learning
Data mining: practical machine learning tools and techniques with Java implementations
Data mining: practical machine learning tools and techniques with Java implementations
Computational Biology and Chemistry
International Journal of Computational Intelligence in Bioinformatics and Systems Biology
BIRD'07 Proceedings of the 1st international conference on Bioinformatics research and development
A novel method for classifying subfamilies and sub-subfamilies of g-protein coupled receptors
ISBMDA'06 Proceedings of the 7th international conference on Biological and Medical Data Analysis
Prediction and classification for GPCR sequences based on ligand specific features
ISCIS'06 Proceedings of the 21st international conference on Computer and Information Sciences
EuroGP'06 Proceedings of the 2006 international conference on Applications of Evolutionary Computing
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G-protein coupled receptors (GPCRs) play a key role in different biological processes, such as regulation of growth, death and metabolism of cells. They are major therapeutic targets of numerous prescribed drugs. However, the ligand specificity of many receptors is unknown and there is little structural information available. Bioinformatics may offer one approach to bridge the gap between sequence data and functional knowledge of a receptor. In this paper, we use a bagging classification tree algorithm to predict the type of the receptor based on its amino acid composition. The prediction is performed for GPCR at the sub-family and sub-sub-family level. In a cross-validation test, we achieved an overall predictive accuracy of 91.1% for GPCR sub-family classification, and 82.4% for sub-sub-family classification. These results demonstrate the applicability of this relative simple method and its potential for improving prediction accuracy.