A competition model of HIV with recombination effect

Authors:
Feng Wang;Zhien Ma;Yiming Shag
Affiliations:
Department of Applied Mathematics, Xi'an Jiaotong University Xi'an, Shaan'xi 710049, P.R. China;Department of Applied Mathematics, Xi'an Jiaotong University Xi'an, Shaan'xi 710049, P.R. China;NCAIDS, Chinese Centers for Disease Control and Prevention Nanwei Road No. 27, Xuanwu District, Beijing, 100050, P.R. China
Venue:
Mathematical and Computer Modelling: An International Journal
Year:
2003

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Abstract

An autonomous model of HIV recombination is proposed and analyzed. The necessary and sufficient conditions for the existence of all equilibria are obtained. Stability and global attraction of these equilibria are also fully studied. The principle of competitive exclusion is no longer valid, interclade recombination effect confers competitive advantages to the recombinant virus. An optimal vaccine strategy also is suggested.