A nonperturbative analytical solution of immune response with time-delays and possible generalization

  • Authors:
  • G. Adomian;Y. Cherruault;K. Abbaoui

  • Affiliations:
  • General Analytics Corporation 155 Clyde Road, Athens, GA 30605, U.S.A.;Université Pierre et Marie Curie, MEDIMAT 15 rue de l'Ecole de Médecine, 75270 Paris cédex 06, France;Université Pierre et Marie Curie, MEDIMAT 15 rue de l'Ecole de Médecine, 75270 Paris cédex 06, France

  • Venue:
  • Mathematical and Computer Modelling: An International Journal
  • Year:
  • 1996

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Abstract

Mathematical models of the dynamic interaction of immune response with a population of bacteria, viruses, antigens, or tumor cells have been modelled as systems of nonlinear differential equations or delay-differential equations. Such models can be solved analytically without resorting to linearization, perturbation, discretization, or restrictions on stochasticity, such as Wiener processes or closure approximations, which change the problem supposedly being solved so the solution is not necessarily physically realistic. With the availability of an analytical solution method with the potential to solve more general models, more attention can be devoted to modelling which may more fully represent the complexity of the interactions involved.