A computational algorithm for functional inequality constrained optimization problems
Automatica (Journal of IFAC)
A new computational algorithm for functional inequality constrained optimization problems
Automatica (Journal of IFAC)
Numerical computation of optimal feed rates for a fed-batch fermentation model
Journal of Optimization Theory and Applications
Optimal control for nonlinear dynamical system of microbial fed-batch culture
Journal of Computational and Applied Mathematics
A multistage system of microbial fed-batch fermentation and its parameter identification
Mathematics and Computers in Simulation
Automatica (Journal of IFAC)
Optimal piecewise state feedback control for impulsive switched systems
Mathematical and Computer Modelling: An International Journal
Issues in the real-time computation of optimal control
Mathematical and Computer Modelling: An International Journal
Control parameterization enhancing transform for optimal control of switched systems
Mathematical and Computer Modelling: An International Journal
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The mathematical model and optimal control of microbial fed-batch fermentation is considered in this paper. Since it is decisive for increasing the productivity of 1,3-propanediol (1,3-PD) to optimize the feeding rate of glycerol and the switching instants between the batch and feeding processes in the fermentation process, we propose a new nonlinear dynamical system to formulate the process. In the system, the switching instants are variable and the feed rate of glycerol is regarded as the control function. Some important properties of the proposed system and its solution are then discussed. To maximize the concentration of 1,3-PD at the terminal time, an optimal control model involving the proposed system and subject to continuous state inequality constraints is established. The existence of the optimal control of the model is also proved. Finally, a computational approach is constructed on the basis of constraint transcription and smoothing approximation techniques. Numerical results show that the concentration of 1,3-PD at the terminal time can be increased considerably.