Group Study of Simulated Driving fMRI Data by Multiset Canonical Correlation Analysis

Authors:
Yi-Ou Li;Tom Eichele;Vince D. Calhoun;Tulay Adali
Affiliations:
Department of Computer Science and Electrical Engineering, University of Maryland Baltimore County, Baltimore, USA 21250;Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway 5011;The Mind Research Network, Albuquerque, USA 87106 and Department of Electrical and Computer Engineering, University of New Mexico, Albuquerque, USA and Department of Psychiatry, Yale University Sc ...;Department of Computer Science and Electrical Engineering, University of Maryland Baltimore County, Baltimore, USA 21250
Venue:
Journal of Signal Processing Systems
Year:
2012

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Abstract

In this work, we apply a novel statistical method, multiset canonical correlation analysis (M-CCA), to study a group of functional magnetic resonance imaging (fMRI) datasets acquired during simulated driving task. The M-CCA method jointly decomposes fMRI datasets from different subjects/sessions into brain activation maps and their associated time courses, such that the correlation in each group of estimated activation maps across datasets is maximized. Therefore, the functional activations across all datasets are extracted in the order of consistency across different dataset. On the other hand, M-CCA preserves the uniqueness of the functional maps estimated from each dataset by avoiding concatenation of different datasets in the analysis. Hence, the cross-dataset variation of the functional activations can be used to test the hypothesis of functional-behavioral association. In this work, we study 120 simulated driving fMRI datasets and identify parietal-occipital regions and frontal lobe as the most consistently engaged areas across all the subjects and sessions during simulated driving. The functional-behavioral association study indicates that all the estimated brain activations are significantly correlated with the steering operation during the driving task. M-CCA thus provides a new approach to investigate the complex relationship between the brain functions and multiple behavioral variables, especially in naturalistic tasks as demonstrated by the simulated driving study.