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Performance analysis of multiuser orthogonal frequency division multiplexing (OFDM-TDMA) and orthogonal frequency division multiple access (OFDMA) networks in support of multimedia transmission is conducted in this work. We take a cross-layer approach and analyze several quality-of-service (QoS) measures that incilude the bit rate and the bit error rate (BER) in the physical layer, and packet average throughput/delay and packet maximum delay in the link layer. The authors adopt a cross-layer QoS framework similar to that in IEEE 802.16, where service classification, flow control and opportunistic scheduling with different subcarrier/bit allocation schemes are implemented. In the analysis, the Rayleigh fading channel in the link layer is modeled by a finite-state Markov chain, and the channel state information (CSI) is assumed to be available at the base station. With the M/G/1 queueing model and flow control results, the analysis provides important insights into the performance difference of these two multiaccess systems. The derived analytical results are verified by extensive computer simulation. It is demonstrated by analysis and simulation that OFDMA outperforms OFDM-TDMA in QoS metrics of interest. Thus, OFDMA has higher potential than OFDM-TDMA in supporting multimedia services.