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The problem of inverting trained feedforward neural networks is to find the inputs which yield a given output. In general, this problem is an ill-posed problem. We present a method for dealing with the inverse problem by using mathematical programming techniques. The principal idea behind the method is to formulate the inverse problem as a nonlinear programming problem, a separable programming (SP) problem, or a linear programming problem according to the architectures of networks to be inverted or the types of network inversions to be computed. An important advantage of the method over the existing iterative inversion algorithm is that various designated network inversions of multilayer perceptrons and radial basis function neural networks can be obtained by solving the corresponding SP problems, which can be solved by a modified simplex method. We present several examples to demonstrate the proposed method and applications of network inversions to examine and improve the generalization performance of trained networks. The results show the effectiveness of the proposed method