Cross-Contamination Aware Design Methodology for Pin-Constrained Digital Microfluidic Biochips

Authors:
C. C.-Y. Lin; Yao-Wen Chang
Affiliations:
Dept. of Electr. Eng., Stanford Univ., Stanford, CA, USA;-
Venue:
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
Year:
2011

Citing 0
Cited 4

Design of pin-constrained general-purpose digital microfluidic biochips

Proceedings of the 49th Annual Design Automation Conference
Reactant minimization during sample preparation on digital microfluidic biochips using skewed mixing trees

Proceedings of the International Conference on Computer-Aided Design
Optimization algorithms for the design of digital microfluidic biochips: A survey

Computers and Electrical Engineering
A field-programmable pin-constrained digital microfluidic biochip

Proceedings of the 50th Annual Design Automation Conference

Quantified Score

Hi-index	0.03

Visualization

Abstract

Digital microfluidic biochips have emerged as a popular alternative for laboratory experiments. Pin-count reduction and cross-contamination avoidance are key design considerations for practical applications with different droplets being transported and manipulated on highly integrated biochips. This paper presents the first design automation flow that considers the cross-contamination problems on pin-constrained biochips. The factors that make the problems harder on pin-constrained biochips are explored. To cope with these cross contaminations, this paper proposes: 1) early crossing minimization algorithms during placement, and 2) systematic wash droplet scheduling and routing that require only one extra control pin and zero assay completion time overhead for practical bioassays. Experimental results show the effectiveness and scalability of our algorithms for practical bioassays.