Mixtures of Gaussian wells: Theory, computation, and application

  • Authors:
  • Ioanna Manolopoulou;Thomas B. Kepler;Daniel M. Merl

  • Affiliations:
  • Department of Statistical Science, Duke University, United States;Department of Microbiology, Boston University School of Medicine, United States;Applied Statistics Group, Lawrence Livermore National Laboratory, United States

  • Venue:
  • Computational Statistics & Data Analysis
  • Year:
  • 2012

Quantified Score

Hi-index 0.03

Visualization

Abstract

A primary challenge in unsupervised clustering using mixture models is the selection of a family of basis distributions flexible enough to succinctly represent the distributions of the target subpopulations. In this paper we introduce a new family of Gaussian well distributions (GWDs) for clustering applications where the target subpopulations are characterized by hollow (hyper-)elliptical structures. We develop the primary theory pertaining to the GWD, including mixtures of GWDs, selection of prior distributions, and computationally efficient inference strategies using Markov chain Monte Carlo. We demonstrate the utility of our approach, as compared to standard Gaussian mixture methods on a synthetic dataset, and exemplify its applicability on an example from immunofluorescence imaging, emphasizing the improved interpretability and parsimony of the GWD-based model.