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As supply chains become longer (both conceptually and geographically), more complex, and more important to the financial health of companies participating in them, the efficiency of operations in warehouses correspondingly increases in importance. Historically, it did not take long for simulation technology, originally heavily used in the analysis of manufacturing operations, to earn high regard as a powerful analytical tool for the improvement of warehouse operations. In the study examined in this paper, a warehouse accepts a variety of product shipments which must travel along conveyors to be protectively stretch-wrapped before they are stored for later picking. Simulation and its accompanying statistical techniques were used to assess and optimize the configuration of machines, material-handling equipment, and labor.