Mapping Partners Master Drug Dictionary to RxNorm using an NLP-based approach

  • Authors:

  • Li Zhou;Joseph M. Plasek;Lisa M. Mahoney;Frank Y. Chang;Dana Dimaggio;Roberto A. Rocha

  • Affiliations:

  • Clinical Informatics Research & Development, Partners HealthCare System, Inc., Wellesley, United States and Division of General Medicine and Primary Care, Brigham and Women's Hospital Harvard Medi ...;Clinical Informatics Research & Development, Partners HealthCare System, Inc., Wellesley, United States;Clinical Informatics Research & Development, Partners HealthCare System, Inc., Wellesley, United States;Clinical Informatics Research & Development, Partners HealthCare System, Inc., Wellesley, United States;Clinical Informatics Research & Development, Partners HealthCare System, Inc., Wellesley, United States;Clinical Informatics Research & Development, Partners HealthCare System, Inc., Wellesley, United States and Division of General Medicine and Primary Care, Brigham and Women's Hospital Harvard Medi ...

  • Venue:
  • Journal of Biomedical Informatics
  • Year:
  • 2012

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Abstract

Objective: To develop an automated method based on natural language processing (NLP) to facilitate the creation and maintenance of a mapping between RxNorm and a local medication terminology for interoperability and meaningful use purposes. Methods: We mapped 5961 terms from Partners Master Drug Dictionary (MDD) and 99 of the top prescribed medications to RxNorm. The mapping was conducted at both term and concept levels using an NLP tool, called MTERMS, followed by a manual review conducted by domain experts who created a gold standard mapping. The gold standard was used to assess the overall mapping between MDD and RxNorm and evaluate the performance of MTERMS. Results: Overall, 74.7% of MDD terms and 82.8% of the top 99 terms had an exact semantic match to RxNorm. Compared to the gold standard, MTERMS achieved a precision of 99.8% and a recall of 73.9% when mapping all MDD terms, and a precision of 100% and a recall of 72.6% when mapping the top prescribed medications. Conclusion: The challenges and gaps in mapping MDD to RxNorm are mainly due to unique user or application requirements for representing drug concepts and the different modeling approaches inherent in the two terminologies. An automated approach based on NLP followed by human expert review is an efficient and feasible way for conducting dynamic mapping.