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In spite of the advancement and variety of available mobile based applications, there is an eminent need to investigate the current position of the acceptance of those mobile health applications that are tailored towards the patients' medical information management and access. This paper explores and analysis the technology acceptance of the use of smart mobile phones from users' perceptions, viewpoint, and experience. The paper will focus on studies of the factors affecting the intention to use the smart mobile phone in the medical domain. Our proposed Mobile Technology Acceptance Model (Mo-HTAM) assessed the significance of the correlation between technology design, perceived ease of use, perceived usefulness as independent factors and the intention to use m-Health services as the dependent factor. The correlation coefficient analysis indicated that there is a significant relationship between the major constructs. Rigorous analytical testing confirmed that there is a direct relationship between social, cultural and technological constructs with intention to use m-Health applications. The model indicated that a well-informed technology design will increase the intention to use m-Health application, and perceived usefulness is more significant to the intention to use m-health applications than the perceived ease of use. These findings indicated that intention to use mobile health informatics is formed by the perceptions of the user of m-Health technology design approach, especially in relation to the navigation and the data presentation on the mobile device.