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This paper presents definitions characterizing the concepts regarding cyber-physical systems and dependability. Cyber-physical systems incorporate computing, communication and storage capabilities with monitoring and/or control of entities in the physical world in a dependably, securely, efficiently and real-time way. The challenges of cyber-physical system research are concerning: real-time system abstractions; robustness, safety and security; QoS composition; and nor least dependability. Dependability is first introduced as a global concept that subsumes the usual attributes of reliability, availability, safety, integrity and maintainability. The paper aims to define research challenges to achieve the dependability in cyber-physical hydropower systems. The significant challenge of the dependability in cyber-physical hydropower systems is evaluation of the system behavior in terms of interdependencies between cyber and physical components of the system.