Optimum Image Thresholding via Class Uncertainty and Region Homogeneity
IEEE Transactions on Pattern Analysis and Machine Intelligence
A Gaussian kernel-based fuzzy c-means algorithm with a spatial bias correction
Pattern Recognition Letters
IPMI '09 Proceedings of the 21st International Conference on Information Processing in Medical Imaging
Active contours driven by local Gaussian distribution fitting energy
Signal Processing
Generalized scale: Theory, algorithms, and application to image inhomogeneity correction
Computer Vision and Image Understanding
IEEE Transactions on Systems, Man, and Cybernetics, Part B: Cybernetics
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Automated segmentation of brain MR images into gray matter, white matter and cerebrospinal fluid (CSF) has been extensively studied with many algorithms being proposed. However, most of those algorithms suffer from limited accuracy, due to the presence of intrinsic noise, low contrast and intensity inhomogeneity (INU) in MR images. In this paper, we propose the local Gaussian distribution fitting based fuzzy c-means (LGDFFCM) algorithm for automated and accurate brain MR image segmentation. In this algorithm, an energy function is defined by using the kernel function to characterize the fitting of local Gaussian distributions to the local image data within the neighborhood of each pixel. A new local scale computing method is developed to estimate the variances of local Gaussian distributions. We compared our algorithm to several state-of-the-art segmentation approaches in both synthetic and clinical data. Our results show that the proposed LGDFFCM algorithm can substantially reduce the impact of by noise, low contrast and INU, and produce satisfying segmentation of brain MR images.