Prognostic modeling with high dimensional and censored data

  • Authors:
  • Leon Bobrowski;Tomasz Łukaszuk

  • Affiliations:
  • Faculty of Computer Science, Bialystok University of Technology, Bialystok, Poland,Institute of Biocybernetics and Biomedical Engineering, PAS, Warsaw, Poland;Faculty of Computer Science, Bialystok University of Technology, Bialystok, Poland

  • Venue:
  • ICDM'12 Proceedings of the 12th Industrial conference on Advances in Data Mining: applications and theoretical aspects
  • Year:
  • 2012

Quantified Score

Hi-index 0.00

Visualization

Abstract

Designing linear prognostic models on the base of multivariate learning set with censored dependent variable is considered in the paper. The task of linear regression model designing has been reformulated here as a problem of testing the linear separability of two sets. The convex and piecewise linear (CPL) criterion functions are used here both for estimation of the model parameters and for the feature selection task. The feature selection is aimed on neglecting a possibly large amount of independent variables while improving resulting model quality. Particular attention is paid to modeling censored data used in survival analysis. Experiments with the use of the RLS method of gene subset selection in prognostic model selection with the censored dependent variable is also described in the paper.