An eigengene-based classifier committee learning algorithm for tumor classification

Authors:
Zhan-Li Sun;Ting-Ting Sun;Yang Liu
Affiliations:
School of Electrical Engineering and Automation, Anhui University, China;School of Electrical Engineering and Automation, Anhui University, China;School of Electrical Engineering and Automation, Anhui University, China
Venue:
ICIC'12 Proceedings of the 8th international conference on Intelligent Computing Theories and Applications
Year:
2012

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Abstract

This paper presents a tumor classification approach by using eigengene and support vector machine (SVM) based classifier committee learning (CCL) algorithm. In this method, first, multiple sample feature subspaces of gene expression data are extracted by random subspace method. Then, the gene expression data constructed by these subspaces are modeled by independent component analysis (ICA), respectively. And the corresponding eigengene sets are extracted by the ICA algorithm. Finally, Bayesian sum rule (BSR) based SVM CCL algorithm is applied on these feature sets and the unknown labels are predicted. Experimental results on two DNA microarray datasets demonstrate that the proposed method is efficient and feasible for the tumor classification.