Bioinformatics: the machine learning approach
Bioinformatics: the machine learning approach
Numerical Recipes in C++: the art of scientific computing
Numerical Recipes in C++: the art of scientific computing
Neural Networks: A Comprehensive Foundation
Neural Networks: A Comprehensive Foundation
Pattern Discovery in Biomolecular Data: Tools, Techniques, and Applications
Pattern Discovery in Biomolecular Data: Tools, Techniques, and Applications
A SVM for GPCR Protein Prediction Using Pattern Discovery
HIS '08 Proceedings of the 2008 8th International Conference on Hybrid Intelligent Systems
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Artificial neural networks have been applied, as solutions, in several different problems within the field of bioinformatics. Similarly, pattern discovery algorithms have also been used to uncover hidden motifs in protein sequences, which have further contributed to understanding the problem of classification of different protein sequences. G-protein coupled receptors (GPCRs) represent one of the largest protein families in the Human Genome. Most of these receptors are major targets for drug discovery and development; therefore, they are of interest to the pharmaceutical industry. The technique used in this article combines both: neural network and pattern discovery methods to develop a protein prediction procedure in relation to its functional class, more specifically, to predict the GPCR protein. Vilo [2] proposed an algorithm to extract patterns of regular expressions from known GPCR protein sequences. Our contribution in this article is to combine these patterns as features for a neural network. We select patterns through the PCA (Principal Component Analysis) procedure and produce a learning machine for the prediction of the GPCR super class.