Agent-based model of macrophage action on endocrine pancreas

  • Authors:

  • Ignacio V. Martí/-nez;Enrique J. Gó/mez;M. Elena Hernando;Ricardo Villares;Mario Mellado

  • Affiliations:

  • Grupo de Bioingenierí/-a y Telemedicina, Departamento de Tecnologí/-a Fotó/nica, Universidad Polité/cnica de Madrid, Avenida Complutense 30, 28040 Madrid, Spain/ Centro de Investig ...;Grupo de Bioingenierí/-a y Telemedicina, Departamento de Tecnologí/-a Fotó/nica, Universidad Polité/cnica de Madrid, Avenida Complutense 30, 28040 Madrid, Spain/ Centro de Investig ...;Grupo de Bioingenierí/-a y Telemedicina, Departamento de Tecnologí/-a Fotó/nica, Universidad Polité/cnica de Madrid, Avenida Complutense 30, 28040 Madrid, Spain/ Centro de Investig ...;Departamento de Inmunologí/-a y Oncologí/-a, Centro Nacional de Biotecnologí/-a/CSIC, Calle Darwin 3, Lab 416, 28049 Madrid, Spain;Departamento de Inmunologí/-a y Oncologí/-a, Centro Nacional de Biotecnologí/-a/CSIC, Calle Darwin 3, Lab 416, 28049 Madrid, Spain

  • Venue:
  • International Journal of Data Mining and Bioinformatics
  • Year:
  • 2012

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Abstract

This paper proposes an agent-based model of the action of macrophages on the beta cells of the endocrine pancreas. The aim of this model is to simulate the processes of beta cell proliferation and apoptosis and also the process of phagocytosis of cell debris by macrophages, all of which are related to the onset of the autoimmune response in type 1 diabetes. We have used data from the scientific literature to design the model. The results show that the model obtains good approximations to real processes and could be used to shed light on some open questions concerning such processes.