Discovering geometric patterns in genomic data

  • Authors:
  • Wenxuan Gao;Lijia Ma;Christopher Brown;Matthew Slattery;Philip S. Yu;Robert L. Grossman;Kevin P. White

  • Affiliations:
  • University of Illinois at Chicago;Institute for Genomics & Systems Biology;Institute for Genomics & Systems Biology;Institute for Genomics & Systems Biology;University of Illinois at Chicago;Institute for Genomics & Systems Biology;Institute for Genomics & Systems Biology

  • Venue:
  • Proceedings of the ACM Conference on Bioinformatics, Computational Biology and Biomedicine
  • Year:
  • 2012

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Abstract

ChIP-chip and ChIP-seq are techniques for the isolation and identification of the binding sites of DNA-associated proteins along the genome. Both techniques produce genome-wide location data. The geometric arrangements of these binding sites can provide valuable information about biological function, such as the activation or repression of genes. In this paper, we formalize this problem and propose a novel graph based algorithm called Patterns of Marks (PoM) to discover efficiently these types of geometric patterns in genomic data. We also describe how we validate the algorithm using experimental data.