Towards sequence-based DNA flexibility analysis

Authors:
Emily Flynn;Filip Jagodzinski;Ileana Streinu
Affiliations:
Smith College, Northampton, MA;Central Washington University, Ellensburg, WA;Smith College & UMass, Northampton & Amherst, MA
Venue:
Proceedings of the ACM Conference on Bioinformatics, Computational Biology and Biomedicine
Year:
2012

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Abstract

In this poster, we present an extension to our freely available KINARI-Web server to identify rigid and flexible regions of nucleic acids and protein-nucleic acid complexes contained in the Protein Data Bank (PDB). The goal is to explore the effect of DNA and RNA on the rigidity and stability of these structures. We also propose an approach for determining DNA rigidity based solely on sequence. Currently, only the rigidity of DNA molecules whose structures have been deposited in the PDB (approx.