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This paper addresses the topic of model based design of experiments for the identification of nonlinear dynamic systems. Data driven modeling decisively depends on informative input and output data obtained from experiments. Design of experiments is targeted to generate informative data and to reduce the experimentation effort as much as possible. Furthermore, design of experiments has to comply with constraints on the system inputs and the system output, in order to prevent damage to the real system and to provide stable operational conditions during the experiment. For that purpose a model based approach is chosen for the optimization of excitation signals in this paper. Two different modeling architectures, namely multilayer perceptron networks and local model networks are chosen and the experiment design is based on the optimization of the Fisher information matrix of the associated model architecture. The paper presents and discusses feasible problem formulations and solution approaches for the constrained dynamic design of experiments. In this context the effects of the Fisher information matrix in the static and the dynamic configurations are discussed. The effectiveness of the proposed method is demonstrated on a complex nonlinear dynamic engine simulation model and an analysis as well as a comparison of the presented model architectures for model based experiment design is given.