Mean template for tensor-based morphometry using deformation tensors
MICCAI'07 Proceedings of the 10th international conference on Medical image computing and computer-assisted intervention
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Alzheimer's disease (AD) is characterized both by cortical atrophy and disrupted connectivity, resulting in abnormal interactions between neural systems. Diffusion weighted imaging (DWI) and graph theory can be used to evaluate major brain networks, and detect signs of abnormal breakdown in network connectivity. In a longitudinal study using both DWI and standard MRI, we assessed baseline white matter connectivity patterns in 24 early mild cognitive impairment (eMCI) subjects (mean age: 74.5 +/- 8.3 yrs). Using both standard MRI-based cortical parcellations and whole-brain tractography, we computed baseline connectivity maps from which we calculated global "small-world" architecture measures. We evaluated whether these network measures predicted future volumetric brain atrophy in eMCI subjects, who are at risk for developing AD, as determined by 3D Jacobian "expansion factor maps" between baseline and 6-month follow-up scans. This study suggests that DWI-based network measures may be a novel predictor of AD progression.