Shrinkage algorithms for MMSE covariance estimation
IEEE Transactions on Signal Processing
Connectivity-informed fMRI activation detection
MICCAI'11 Proceedings of the 14th international conference on Medical image computing and computer-assisted intervention - Volume Part II
A supervised clustering approach for fMRI-based inference of brain states
Pattern Recognition
Fiber connectivity integrated brain activation detection
IPMI'13 Proceedings of the 23rd international conference on Information Processing in Medical Imaging
A novel sparse group Gaussian graphical model for functional connectivity estimation
IPMI'13 Proceedings of the 23rd international conference on Information Processing in Medical Imaging
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Despite the clear potential benefits of combining fMRI and diffusion MRI in learning the neural pathways that underlie brain functions, little methodological progress has been made in this direction. In this paper, we propose a novel multimodal integration approach based on sparse Gaussian graphical model for estimating brain connectivity. Casting functional connectivity estimation as a sparse inverse covariance learning problem, we adapt the level of sparse penalization on each connection based on its anatomical capacity for functional interactions. Functional connections with little anatomical support are thus more heavily penalized. For validation, we showed on real data collected from a cohort of 60 subjects that additionally modeling anatomical capacity significantly increases subject consistency in the detected connection patterns. Moreover, we demonstrated that incorporating a connectivity prior learned with our multimodal connectivity estimation approach improves activation detection.