Quantitation of Vessel Morphology from 3D MRA
MICCAI '99 Proceedings of the Second International Conference on Medical Image Computing and Computer-Assisted Intervention
Distance regularized level set evolution and its application to image segmentation
IEEE Transactions on Image Processing
MICCAI'10 Proceedings of the 13th international conference on Medical image computing and computer-assisted intervention: Part III
Automatic cerebrovascular segmentation by accurate probabilistic modeling of TOF-MRA images
MICCAI'05 Proceedings of the 8th international conference on Medical Image Computing and Computer-Assisted Intervention - Volume Part I
MRA image segmentation with capillary active contour
MICCAI'05 Proceedings of the 8th international conference on Medical Image Computing and Computer-Assisted Intervention - Volume Part I
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In current clinical practice, examinations of the carotid artery bifurcation are commonly carried out with Computed Tomography Angiography,(CTA) or contrast-enhanced Magnetic Resonance Angiography (ce, MRA). Quantitative information about vessel morphology, extracted from segmentations, is promising for diagnosis of vessel pathologies. However, both above-mentioned techniques require the administration of contrast media. In contrary, non-ce MRA methods such as Time-of-Flight,(TOF) provide fully non-invasive imaging without any exogenous contrast agent. The diagnostic value of TOF MRA, however, for assessment of the carotid bifurcation area can be hampered due to its susceptibility to irregular blood flow patterns. Conventional methods for lumen segmentation are very sensitive to such signal voids and produce inaccurate results. In this work, a novel, fully automatic 3D segmentation algorithm is proposed which uses prior knowledge about irregular flow patterns. The presented technique has been successfully tested on eleven volunteer datasets as well as in a patient case, offering the comparison to CTA images. The sensitivity could be increased by 29.2% to 85.6% compared to standard level set methods. The root mean squared error in diameter measurements was reduced from 4.85,mm to 1.44,mm.