Study of cancer hallmarks relevance using a cellular automaton tumor growth model

  • Authors:

  • José Santos;Ángel Monteagudo

  • Affiliations:

  • Computer Science Department, University of A Coruña, Spain;Computer Science Department, University of A Coruña, Spain

  • Venue:
  • PPSN'12 Proceedings of the 12th international conference on Parallel Problem Solving from Nature - Volume Part I
  • Year:
  • 2012

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Abstract

We studied the relative importance of the different cancer hallmarks in tumor growth in a multicellular system. Tumor growth was modeled with a cellular automaton which determines cell mitotic and apoptotic behaviors. These behaviors depend on the cancer hallmarks acquired in each cell as consequence of mutations. Additionally, these hallmarks are associated with a series of parameters, and depending on their values and the activation of the hallmarks in each of the cells, the system can evolve to different dynamics. Here we focus on the relevance of each hallmark in the progression of the first avascular phase of tumor growth and in representative situations.