Mathematical Modeling of the Influence of RKIP on the ERK Signaling Pathway
CMSB '03 Proceedings of the First International Workshop on Computational Methods in Systems Biology
Bioinformatics
Bayesian ranking of biochemical system models
Bioinformatics
Target driven biochemical network reconstruction based on petri nets and simulated annealing
Proceedings of the 8th International Conference on Computational Methods in Systems Biology
Parameter Estimation Using Metaheuristics in Systems Biology: A Comprehensive Review
IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB)
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Modelling biochemical systems has received considerable attention over the last decade from scientists and engineers across a number of fields, including biochemistry, computer science, and mathematics. Due to the complexity of biochemical systems, it is natural to construct models of the biochemical systems incrementally in a piecewise manner. This paper proposes a hybrid approach which applies an evolutionary algorithm to select and compose pre-defined building blocks from a library of atomic models, mutating their products, thus generating complex systems in terms of topology, and employs a global optimization algorithm to fit the kinetic rates. Experiments using two signalling pathways show that given target behaviours it is feasible to explore the model space by this hybrid approach, generating a set of synthetic models with alternative structures and similar behaviours to the desired ones.