JAK-STAT signalling as example for a database-supported modular modelling concept

Authors:
Mary Ann Blätke;Anna Dittrich;Monika Heiner;Fred Schaper;Wolfgang Marwan
Affiliations:
Otto-von-Guericke-Universität, Magdeburg, Germany;Otto-von-Guericke-Universität, Magdeburg, Germany;Brandenburg Technical University, Cottbus, Germany;Otto-von-Guericke-Universität, Magdeburg, Germany;Otto-von-Guericke-Universität, Magdeburg, Germany
Venue:
CMSB'12 Proceedings of the 10th international conference on Computational Methods in Systems Biology
Year:
2012

Citing 2
Cited 1

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Abstract

We present a detailed model of the JAK-STAT pathway in IL-6 signaling as non-trivial case study demonstrating a new database-supported modular modeling method. A module is a self-contained and autonomous Petri net, centred around an individual protein. The modelling approach allows to easily generate and modify coherent, executable models composed from a collection of modules and provides numerous options for advanced biomodel engineering.