Modelling trafficking of proteins within the mammalian cell using Bio-PEPA

Authors:
Vashti Galpin
Affiliations:
CSBE/SynthSys and School of Informatics, University of Edinburgh, UK
Venue:
CMSB'12 Proceedings of the 10th international conference on Computational Methods in Systems Biology
Year:
2012

Citing 4
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Abstract

Bio-PEPA [2], a process algebra developed from PEPA [5] is used to model a process occurring in mammalian cells whereby the Src oncoprotein is trafficked between different parts of the cell [9]. Src is associated with cell movement and adhesion between cells which is linked to tumour formation [9]. A useful model of the protein's behaviour can provide predictions for new experimental hypotheses which may improve our understanding, and in time, lead to new therapies for cancer. The aim is to assess the suitability of Bio-PEPA for more detailed modelling of Src trafficking than that of a previous simpler Bio-PEPA model [4].