Animating rotation with quaternion curves
SIGGRAPH '85 Proceedings of the 12th annual conference on Computer graphics and interactive techniques
AVI '00 Proceedings of the working conference on Advanced visual interfaces
Interactive feature specification for focus+context visualization of complex simulation data
VISSYM '03 Proceedings of the symposium on Data visualisation 2003
Interactive Focus+Context Visualization with Linked 2D/3D Scatterplots
CMV '04 Proceedings of the Second International Conference on Coordinated & Multiple Views in Exploratory Visualization
Hierarchical visualization of metabolic networks using virtual reality
Proceedings of the 2006 ACM international conference on Virtual reality continuum and its applications
Visualizing biological pathways: requirements analysis, systems evaluation and research agenda
Information Visualization - Special issue: Bioinformatics visualization
Network Visualization by Semantic Substrates
IEEE Transactions on Visualization and Computer Graphics
Dynamic exploration and editing of KEGG pathway diagrams
Bioinformatics
VisLink: Revealing Relationships Amongst Visualizations
IEEE Transactions on Visualization and Computer Graphics
A novel grid-based visualization approach for metabolic networks with advanced focus&context view
GD'09 Proceedings of the 17th international conference on Graph Drawing
Toward the role of interaction in visual analytics
Proceedings of the Winter Simulation Conference
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Visualizing pathways, i. e. models of cellular functional networks, is a challenging task in computer assisted biomedicine. Pathways are represented as large collections of interwoven graphs, with complex structures present in both the individual graphs and their interconnections. This situation requires the development of novel visualization techniques to allow efficient visual exploration. We present the Caleydo framework, which incorporates a number of approaches to handle such pathways. Navigation in the network of pathways is facilitated by a hierarchical approach which dynamically selects a working set of individual pathways for closer inspection. These pathways are interactively rendered together with visual interconnections in a 2.5D view using graphics hardware acceleration. The layout of individual graphs is not computed automatically, but taken from the KEGG and BioCarta databases, which use layouts that life scientists are familiar with. Therefore they encode essential meta-information. While the KEGG and BioCarta pathways use a pre-defined layout, interactions such as linking+ brushing, neighborhood search or detail on demand are still fully interactive in Caleydo. We have evaluated Caleydo with pathologists working on the determination of unknown gene functions. Informal experiences confirm that Caleydo is useful in both generating and validating such hypotheses. Even though the presented techniques are applied to medical pathways, the proposed way of interaction is not limited to cellular processes and therefore has the potential to open new possibilities in other fields of application.