Power-law scaling of synchronization robustly reproduced in the hippocampal CA3 slice culture model with small-world topology

  • Authors:

  • Toshikazu Samura;Yasuomi D. Sato;Yuji Ikegaya;Hatsuo Hayashi;Takeshi Aihara

  • Affiliations:

  • Tamagawa University Brain Science Institute, Machida, Tokyo, Japan;Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Wakamatsu-ku, Kitakyushu, Japan,Frankfurt Institute for Advanced Studies (FIAS), Johann Wolfgang Goethe Uni ...;Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan;Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Wakamatsu-ku, Kitakyushu, Japan;Tamagawa University Brain Science Institute, Machida, Tokyo, Japan

  • Venue:
  • ICONIP'12 Proceedings of the 19th international conference on Neural Information Processing - Volume Part II
  • Year:
  • 2012

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Abstract

The hippocampal CA3 is a recurrent network included small-world topology. The percentage of co-active neurons in CA3 slice cultures is approximated by power-law. We show that the power-law scaling of synchronization is reproduced in the CA3 slice culture model where synaptic weights are log-normally distributed and balanced excitation/inhibition regardless of network topologies. However, small-world topology improves the robustness of the reproduction of the power-law scaling in the culture model. Power-law scaling is known as a sign of optimization of a network for information processing. These results suggest that CA3 may be robustly optimized for information processing by excitation/inhibition balance, log-normally distributed synaptic weights and small-world topology.