Activation detection on fMRI time series using hidden Markov model

Authors:
Rong Duan;Hong Man
Affiliations:
AT&T Labs, Florham Park, NJ;Department of Electrical and Computer Engineering, Stevens Institute of Technology, Hoboken, NJ
Venue:
Advances in Artificial Neural Systems - Special issue on Advances in Unsupervised Learning Techniques Applied to Biosciences and Medicine
Year:
2012

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Abstract

This paper introduces two unsupervised learning methods for analyzing functional magnetic resonance imaging (fMRI) data based on hidden Markov model (HMM). HMM approach is focused on capturing the first-order statistical evolution among the samples of a voxel time series, and it can provide a complimentary perspective of the BOLD signals. Two-state HMM is created for each voxel, and the model parameters are estimated from the voxel time series and the stimulus paradigm. Two different activation detection methods are presented in this paper. The first method is based on the likelihood and likelihood-ratio test, in which an additional Gaussian model is used to enhance the contrast of the HMM likelihood map. The secondmethod is based on certain distance measures between the two state distributions, in which the most likely HMM state sequence is estimated through the Viterbi algorithm. The distance between the on-state and off-state distributions is measured either through a t-test, or using the Kullback-Leibler distance (KLD). Experimental results on both normal subject and brain tumor subject are presented. HMM approach appears to be more robust in detecting the supplemental active voxels comparing with SPM, especially for brain tumor subject.