Artificial Intelligence - On connectionist symbol processing
Mental leaps: analogy in creative thought
Mental leaps: analogy in creative thought
Using latent semantic indexing for literature based discovery
Journal of the American Society for Information Science
Binary Spatter-Coding of Ordered K-Tuples
ICANN 96 Proceedings of the 1996 International Conference on Artificial Neural Networks
Holographic Reduced Representation: Distributed Representation for Cognitive Structures
Holographic Reduced Representation: Distributed Representation for Cognitive Structures
Journal of Biomedical Informatics - Special issue: Unified medical language system
Journal of Biomedical Informatics
Arguments of nominals in semantic interpretation of biomedical text
BioNLP '10 Proceedings of the 2010 Workshop on Biomedical Natural Language Processing
Finding schizophrenia's Prozac: emergent relational similarity in predication space
QI'11 Proceedings of the 5th international conference on Quantum interaction
DS'05 Proceedings of the 8th international conference on Discovery Science
Discovering discovery patterns with predication-based Semantic Indexing
Journal of Biomedical Informatics
Real, complex, and binary semantic vectors
QI'12 Proceedings of the 6th international conference on Quantum Interaction
Discovering discovery patterns with predication-based Semantic Indexing
Journal of Biomedical Informatics
Real, complex, and binary semantic vectors
QI'12 Proceedings of the 6th international conference on Quantum Interaction
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This paper addresses the issue of analogical inference, and its potential role as the mediator of new therapeutic discoveries, by using disjunction operators based on quantum connectives to combine many potential reasoning pathways into a single search expression. In it, we extend our previous work in which we developed an approach to analogical retrieval using the Predication-based Semantic Indexing (PSI) model, which encodes both concepts and the relationships between them in high-dimensional vector space. As in our previous work, we leverage the ability of PSI to infer predicate pathways connecting two example concepts, in this case comprising of known therapeutic relationships. For example, given that drug x TREATS disease z, we might infer the predicate pathway drug x INTERACTS_WITH gene y ASSOCIATED_WITH disease z, and use this pathway to search for drugs related to another disease in similar ways. As biological systems tend to be characterized by networks of relationships, we evaluate the ability of quantum-inspired operators to mediate inference and retrieval across multiple relations, by testing the ability of different approaches to recover known therapeutic relationships. In addition, we introduce a novel complex vector based implementation of PSI, based on Plate's Circular Holographic Reduced Representations, which we utilize for all experiments in addition to the binary vector based approach we have applied in our previous research.