Inference of gene regulatory networks using s-system and differential evolution
GECCO '05 Proceedings of the 7th annual conference on Genetic and evolutionary computation
GSA: A Gravitational Search Algorithm
Information Sciences: an International Journal
Evolutionary hidden information detection by granulation-based fitness approximation
Applied Soft Computing
A gravitational approach to edge detection based on triangular norms
Pattern Recognition
Filter modeling using gravitational search algorithm
Engineering Applications of Artificial Intelligence
Parameter Estimation Using Metaheuristics in Systems Biology: A Comprehensive Review
IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB)
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The interaction mechanisms at the molecular level that govern essential processes inside the cell are conventionally modeled by nonlinear dynamic systems of coupled differential equations. Our implementation adopts an S-system to capture the dynamics of the gene regulatory network (GRN) of interest. To identify a solution to inverse problem of GRN parameter identification the gravitational search algorithm (GSA) is adopted here. Contributions made in the present paper are twofold. Firstly the bias of GSA toward the center of the search space is reported. Secondly motivated by observed center-seeking (CS) bias of GSA, mass-dispersed gravitational search algorithm (mdGSA) is proposed here. Simulation results on a set of well-studied mathematical benchmark problems and two gene regulatory networks confirms that the proposed mdGSA is superior to the standard GSA, mainly duo to its reduced CS bias.