SIAM Journal on Scientific Computing
Solving Index-1 DAEs in MATLAB and Simulink
SIAM Review
Simulation of complex pharmacokinetic models in Microsoft EXCEL
Computer Methods and Programs in Biomedicine
PKSolver: An add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel
Computer Methods and Programs in Biomedicine
Computer Methods and Programs in Biomedicine
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Effective communication of PK/PD principles and results in a biomedical research environment remains a significant challenge which can result in lack of buy-in and engagement from scientists outside the modeling and simulation communities. In our view, one of the barriers in this area is a lack of user-friendly tools which allow ''non experts'' to use PK/PD models without the need to develop technical skills and expertise in advanced mathematical principles and specialist software. The costs of commercial software may also prevent large-scale distribution. One attempt to address this issue internally in our research organizations has resulted in the development of the A4S (''Accelera for Sandwich'') software, which is a simple-to-use, menu-drive Matlab-based PK/PD simulator targeted at biomedical researchers with little PK/PD experience.