MATLAB-implemented estimation procedure for model-based assessment of hepatic insulin degradation from standard intravenous glucose tolerance test data

  • Authors:

  • Francesco Di Nardo;Michele Mengoni;Micaela Morettini

  • Affiliations:

  • Department of Information Engineering, Universití Politecnica delle Marche, 60131 Ancona, Italy;Department of Information Engineering, Universití Politecnica delle Marche, 60131 Ancona, Italy;Department of Information Engineering, Universití Politecnica delle Marche, 60131 Ancona, Italy

  • Venue:
  • Computer Methods and Programs in Biomedicine
  • Year:
  • 2013

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Abstract

Present study provides a novel MATLAB-based parameter estimation procedure for individual assessment of hepatic insulin degradation (HID) process from standard frequently-sampled intravenous glucose tolerance test (FSIGTT) data. Direct access to the source code, offered by MATLAB, enabled us to design an optimization procedure based on the alternating use of Gauss-Newton's and Levenberg-Marquardt's algorithms, which assures the full convergence of the process and the containment of computational time. Reliability was tested by direct comparison with the application, in eighteen non-diabetic subjects, of well-known kinetic analysis software package SAAM II, and by application on different data. Agreement between MATLAB and SAAM II was warranted by intraclass correlation coefficients =0.73; no significant differences between corresponding mean parameter estimates and prediction of HID rate; and consistent residual analysis. Moreover, MATLAB optimization procedure resulted in a significant 51% reduction of CV% for the worst-estimated parameter by SAAM II and in maintaining all model-parameter CV%