Fuzzy C-means method with empirical mode decomposition for clustering microarray data

  • Authors:
  • Yan-Fei Wang;Zu-Guo Yu;Vo Anh

  • Affiliations:
  • Discipline of Mathematical Sciences, Faculty of Science and Technology, Queensland University of Technology, Brisbane Q4001, Australia;Discipline of Mathematical Sciences, Faculty of Science and Technology, Queensland University of Technology, Brisbane Q4001, Australia/ School of Mathematics and Computational Science, Xiangtan Un ...;Discipline of Mathematical Sciences, Faculty of Science and Technology, Queensland University of Technology, Brisbane Q4001, Australia

  • Venue:
  • International Journal of Data Mining and Bioinformatics
  • Year:
  • 2013

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Abstract

Microarray techniques have revolutionised genomic research by making it possible to monitor the expression of thousands of genes in parallel. The Fuzzy C-Means FCM method is an efficient clustering approach devised for microarray data analysis. However, microarray data contains noise, which would affect clustering results. In this paper, we propose to combine the FCM method with the Empirical Mode Decomposition EMD for clustering microarray data to reduce the effect of the noise. The results suggest the clustering structures of denoised microarray data are more reasonable and genes have tighter association with their clusters than those using FCM only.