An atlas for cardiac MRI regional wall motion and infarct scoring

  • Authors:
  • Pau Medrano-Gracia;Avan Suinesiaputra;Brett Cowan;David Bluemke;Alejandro Frangi;Daniel Lee;João Lima;Alistair Young

  • Affiliations:
  • Auckland Bioengineering Inst., University of Auckland, New Zealand;Auckland Bioengineering Inst., University of Auckland, New Zealand;Auckland Bioengineering Inst., University of Auckland, New Zealand;NIH Clinical Ctr., Bethesda, MD;Dept. of Mechanical Engineering, University of Sheffield, United Kingdom;Feinberg Cardiovascular Research Inst., Northwestern University, Chicago, IL;Donald W. Reynolds Research Ctr., Johns Hopkins University, Baltimore, MD;Auckland Bioengineering Inst., University of Auckland, New Zealand

  • Venue:
  • STACOM'12 Proceedings of the third international conference on Statistical Atlases and Computational Models of the Heart: imaging and modelling challenges
  • Year:
  • 2012

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Regional wall motion and infarct scoring of MR images are routine clinical tools to grade performance and scarring in the heart. The aim of this paper is to provide a framework for automatic scoring to alert the diagnostician to potential regions of abnormality. We investigated different shape and motion configurations of a finite-element cardiac atlas of the left ventricle. Two patient populations were used: 300 asymptomatic volunteers and 105 patients with myocardial infarction, both randomly selected from the Cardiac Atlas Project database. Support vector machines were employed to estimate the boundaries between the asymptomatic control and patient groups for each of 16 standard anatomical regions in the heart. Ground truth visual wall motion scores from standard cines and infarct scoring from late enhancement were provided by experienced observers. From all configurations, end-systolic shape best predicted wall motion abnormalities (global accuracy 78%, positive predictive value 85%, specificity 91%, sensitivity 60%) and infarct scoring (74%, 72%, 91%, 44%). In conclusion, computer assisted wall motion and infarct scoring has the potential to provide robust identification of those segments requiring further clinical attention; in particular, the high specificity and relatively low sensitivity could help avoid unnecessary late gadolinium rescanning of patients.