BoneNET: a network model of bone microstructure and dynamics

Authors:
Taehyong Kim;Lawrence Bone;Murali Ramanathan;Aidong Zhang
Affiliations:
Department of Computer Science and Engineering, State University of New York at Buffalo, 201 Bell Hall, Buffalo 14260-2000, New York, USA;Department of Orthopedics, State University of New York at Buffalo, 462 Grider Street, Buffalo 14215, New York, USA;Department of Pharmaceutical Sciences, State University of New York at Buffalo, 517 Hochstetter Hall, Buffalo 14260-1200, New York, USA;Department of Computer Science and Engineering, State University of New York at Buffalo, 201 Bell Hall, Buffalo 14260-2000, New York, USA
Venue:
International Journal of Data Mining and Bioinformatics
Year:
2013

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Abstract

We develop a network model of bone microstructure and dynamics, BoneNET, which is capable of quantitative assessment of Bone Mineral Density BMD and bone remodelling dynamics. First, we introduce a network model of bone microstructure by describing structural properties and process of bone network modelling. Secondly, we explain a mathematical model of bone microstructure by analysing the density for mineralised fibres of bone microstructure. Finally, we provide a bone remodelling dynamics among osteoblast and osteoclast and study bone networks by proposing several measurements to calculate bone strength and identify critical elements in bone microstructure.